Low Grade Squamous Intraepithelial Lesion

Low Grade Squamous Intraepithelial Lesion is the disorganized cancerous growth  of squamous cells covering the cervix. the cells multiply and cell nuclei form atypical appearance

The cervix is the lower segment of the uterus. It is the surface part is at the bottom of the vagina.

At the neck of the uterus, two different fabrics are joined. The tissue covering the outer portion is squamous exocervical. The fabric which covers the inner portion is the endocervical glandular epithelium. The “junction region” or “transformation zone” is the boundary between these two epithelia.

It is in this area where the abnormal growth of cells of the cervix can be observed.

Low Grade Squamous Intraepithelial Lesion Terminology

  • Intraepithelial lesions of low grades are called LSIL, Low Grade Superficial epthelial Intra-lesion,
  • These lesions were formerly referred to as condyloma, lesions HPV, mild dysplasia or CIN I (Cervical Intra-epithelial Neoplasia).
  • These lesions correspond to the first stage of the precancerous lesion. This stage is not malignant, but if left unattended, it may lead to fatal cancer (Cervical Cancer)

The evolution of low-grade lesions

  • Spontaneous regression in 50% to 60% of the cases,
  • persistence in 20% to 30% of cases
  • Evolution towards a high-grade lesion in about 20% to 30% of cases
  • Evolution to invasive cancer in less than 1% of case

Low Grade Squamous Intraepithelial Lesion Diagnosis

Dysplasia has no symptoms. Cervical dysplasia is not visible to the naked eye. It is visible only under a microscope.

Screening is done by conducting a Pap smear. Consult physician or a gynecologist.

5% of the cases of diagnosis doesn’t show an evidence of cancerous growth. It might just be a false alarm. The patient is then called for a closer examination of the cervix, called “  colposcopy  ” for confirmation.

Other results of the diagnosis include Atypical, Low Grade Squamous Intraepithelial Lesion, High Grade Squamous Intraepithelial Lesion and a few others. These High Grade lesions were formerly known as: CIN II, CIN III, CIS, moderate dysplasia, severe dysplasia.

Low Grade Squamous Lesion is an acute condition and be cured easily. While High Grade Squamous Lesions is an advanced stage of the infection and may lead to cancer.

Low Grade Squamous Intraepithelial Lesion Treatment

The treatment of low-grade dysplasia depends first of concordance between the 3 tests performed: smear, colposcopy and biopsy.

There are two possibilities for the treatment of low-grade dysplasia:

Low-grade dysplasia :

When the three tests are consistent and in favor of a low-grade lesion, whose surface is limited and with a “junction box” perfectly visible, CNGOF (December 2007) recommends treating by laser vaporization if lesions persist for at least 18 months. Treatment with laser is completely painless. It is usually done without anesthesia.

When all initial conditions are not met, treatment by a “  cone biopsy  ” is required.

High-grade dysplasia :

Dysplasia high always require treatment. They require surgery. The procedure involves removing a small area of the cervix ( cone biopsy ). It is often done under general anesthesia.

Different techniques exist conization. The technique used is decided by the surgeon. The choice of technique depends on the extent of the lesion, colposcopic appearance and habits of the surgeon.

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